I really enjoy The Meaning of Lila, an excellent strip helmed by John Forgetta. John works at American Greetings as Editorial Director, and he's a great guy.
Lila is consistently funny, with a nice, contemporary sensiblity. It feels like an update of Cathy, without the endless swimsuit-buying angst.
The Meaning of Lila should be in every paper in the country, IMHO, and if it's not in yours, write your editor and ask for its inclusion. (And while you're at it, ask them to put in Triple Take, too.)